MCP2221A-I/ML Microchip Integrated Circuit (Quad Flat No-Lead) In Stock

Name: MCP2221A-I/ML
Brand: Microchip
SKU: MCP2221A-I/ML
Availability: InStock

The MCP2221A-I/ML is a USB 2.0 full-speed to I2C/UART protocol converter IC from Microchip. Housed in a compact 16-pin QFN package, it provides USB-to-I2C, USB-to-UART, and GPIO bridging at up to 12 MHz, and is ideal for embedded debug interfaces and USB-to-serial adapters.

ACTIVEIntegrated CircuitVerified Jun 2026

Package / Visual Reference

MCP2221A-I/MLQuad Flat No-Lead

Quick Facts

Manufacturer: Microchip
Package: Quad Flat No-Lead
Pin Count: 16
Lifecycle: ACTIVE
Datasheet: MCP2221A-I/ML Datasheet PDF
Category: Integrated Circuit
Price: From $2.0400(MOQ 1)
Temp Range: -40.0°C to 85.0°C
RoHS: Compliant
Lead Time: 3–7 business days
Shipping: DHL Express · Worldwide

What are the key features of MCP2221A-I/ML?

USB 2.0 Full-Speed to I2C, SMBus, and UART bridge in a single IC
Supports I2C clock frequencies up to 400 kHz and UART baud rates up to 115,200 bps
Integrated EEPROM for storing USB descriptor strings and GPIO configuration
4 configurable GPIO pins supporting ADC, DAC, and interrupt-on-change functions
16-pin QFN package with clock frequency up to 12 MHz for compact PCB designs
No external driver required on Windows, Mac, and Linux platforms

What is MCP2221A-I/ML used for?

The MCP2221A-I/ML is widely used as a USB-to-I2C or USB-to-UART debug bridge in embedded system development boards, allowing a PC host to communicate directly with sensors, EEPROMs, and microcontrollers over standard I2C or serial interfaces. It also finds application in industrial data-logging dongles, laboratory instrument front-ends, and IoT gateway prototypes where a low-cost, driver-free USB interface is required.

What are the specifications of MCP2221A-I/ML?

Manufacturer Package Code	VQFN-16
Factory Lead Time	14Weeks
Date Of Intro	2016-06-15
YTEOL	18
Bus Compatibility	I2C; SMBUS; UART; USB
Clock Frequency-Max	12MHz
Data Transfer Rate-Max	1.5MBps
JESD-30 Code	S-PQCC-N16
JESD-609 Code	e3
Package Body Material	PLASTIC/EPOXY
Package Equivalence Code	LCC16,.16SQ,25
Package Shape	SQUARE
Package Style	CHIP CARRIER, HEAT SINK/SLUG, VERY THIN PROFILE
Supply Current-Max	15mA
Supply Voltage-Max	5.5V
Supply Voltage-Min	3V
Supply Voltage-Nom	3.3V
Surface Mount	YES
Technology	CMOS
Temperature Grade	INDUSTRIAL
Terminal Finish	Matte Tin (Sn)
Terminal Form	NO LEAD
Terminal Pitch	0.65mm
Terminal Position	QUAD
uPs/uCs/Peripheral ICs Type	BUS CONTROLLER, UNIVERSAL SERIAL BUS
Package	Quad Flat No-Lead

Compliance & Regulatory

RoHS Status	Compliant
Lead-Free	Yes (Pb-Free)
ECCN	EAR99
HTS Code	8542.39.00.01
Country of Origin	Thailand

Where can I find the MCP2221A-I/ML datasheet?

MCP2221A-I/ML Datasheet Download

Official datasheet from Microchip

What are equivalent replacements for MCP2221A-I/ML?

Compatible alternatives and drop-in replacements for MCP2221A-I/ML:

MCP2221AT-I/MLMicrochip Technology Inc USB

Bus Controller, CMOS, PQCC16

View Part →

Compare all alternatives & request quotes →

Frequently Asked Questions

What communication interfaces does the MCP2221A-I/ML bridge between USB and the target board?

The MCP2221A-I/ML bridges USB 2.0 Full-Speed (up to 12 MHz) to I2C, SMBus, and UART simultaneously, with I2C supporting standard-mode 100 kHz and fast-mode 400 kHz, and UART reaching up to 115,200 bps, covering most low-speed embedded sensor and debug scenarios.

Can the MCP2221A-I/ML replace FTDI or CP2102 USB-to-UART bridges in industrial designs?

Yes. MCP2221A-I/ML adds I2C and SMBus bridging on top of UART, giving it a functional advantage over single-protocol bridges like CP2102. The 16-pin QFN package is also more compact, making it a good fit for space-constrained industrial control panels or handheld instruments.

How does the integrated EEPROM in MCP2221A-I/ML help production programming?

The on-chip EEPROM stores USB Vendor ID, Product ID, manufacturer strings, and GPIO power-up states, so each unit can be programmed once on the production line to enumerate as a custom USB device without firmware overhead, saving at least 1 KB of microcontroller flash that would otherwise hold descriptor tables.

What is the lead time and packaging option for MCP2221A-I/ML in volume procurement?

Microchip lists the MCP2221A-I/ML in a 16-pin VQFN package with a factory lead time of approximately 14 weeks for standard orders, and it was introduced in 2016, so it carries an active lifecycle status. Volume buyers should confirm current stock and pricing with authorized distributors to secure competitive MOQ pricing.

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AvailabilityIn Stock

Reference Price (USD)

From $2.0400

Buy from 1pc · Factory-direct pricing

Qty.	Unit Price	Ext. Price
1+	$2.8000	$2.80
2+	$2.7380	$5.48
25+	$2.2650	$56.63
100+	$2.1300	$213.00
1000+	$2.0500	$2050.00
5000+	$2.0400	$10200.00

pcs

Unit price: $2.8000 · Total: $2.80

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Lead Time3-7 business days

MOQFrom 1 piece

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OriginChina (Authorized)

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MCP2221A-I/ML Microchip Integrated Circuit (Quad Flat No-Lead) In Stock

What are the key features of MCP2221A-I/ML?

What is MCP2221A-I/ML used for?

What are the specifications of MCP2221A-I/ML?

Compliance & Regulatory

Where can I find the MCP2221A-I/ML datasheet?

What are equivalent replacements for MCP2221A-I/ML?

Frequently Asked Questions

What communication interfaces does the MCP2221A-I/ML bridge between USB and the target board?

Can the MCP2221A-I/ML replace FTDI or CP2102 USB-to-UART bridges in industrial designs?

How does the integrated EEPROM in MCP2221A-I/ML help production programming?

What is the lead time and packaging option for MCP2221A-I/ML in volume procurement?

Related Guides

CDSOT23-SM712 RS-485 Interface Protection Design Guide

CR0805-FX-10R0ELF 10 Ohm 0805 Resistor Design Guide

How to Choose Würth Elektronik 150141-Series SMD Indicator LEDs

Molex 53398-0371 Selection Guide: Choosing a 3-Circuit Wire-to-Board Header

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About Microchip

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